摘要 |
Disclosed are novel compounds of the formula: (see formula I) (wherein R1 is aryl, heteroaryl, arylalkyl, heteroarylalkyl, arylaryl or the like; R2 and R3 are each H or alkyl or together form a spiro ring; R4 is H or alkyl), and pharmaceutically acceptable salts and solvates thereof, that are useful, for example, as matrix metalloproteinase inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treatment for diseases such as osteoarthritis, rheumatoid arthritis, cancer, osteoporosis, tissue ulceration, restinosis, periodontal disease, inflammation, epidermolysis bullosa, scleritis, stroke, Alzheimer's disease, and the like, characterized by inappropriate matrix metalloproteinase activity. Processes for the synthesis of compounds of formula (I) are also disclosed.
|