发明名称 |
Utilization of nuclear structural proteins for targeted therapy and detection of proliferative and differentiation disorders |
摘要 |
The localization of nuclear apparatus proteins (NUMA) is used to identify tumor cells and different stages in the tumor progression and differentiation processes. There is a characteristic organization of NuMA in tumor cells and in phenotypically normal cells. NuMA distribution patterns are significantly less diffuse in proliferating non-malignant cells compared to malignant cells. The technique encompasses cell immunostaining using a NuMA specific antibody, and microscopic analysis of NuMA distribution within each nucleus.
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申请公布号 |
US6287790(B1) |
申请公布日期 |
2001.09.11 |
申请号 |
US19990452294 |
申请日期 |
1999.11.30 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
LELIèVRE SOPHIE;BISSELL MINA |
分类号 |
G01N33/574;G01N33/68;(IPC1-7):G01N33/574;G01N33/53;G01N33/567;G01N33/58 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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