发明名称 |
Gardos channel antagonists |
摘要 |
Novel inhibitors of potassium flux are disclosed. The inhibitors show surprising resistance to degradation in biological media and enhanced in vivo half-lives relative to non-fluorine substituted homologues. Methods for the use of these compounds include treating sickle cell disease, preventing erythrocyte dehydration and inhibiting potassium flux.
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申请公布号 |
US6288122(B1) |
申请公布日期 |
2001.09.11 |
申请号 |
US19990386601 |
申请日期 |
1999.08.31 |
申请人 |
ICAGEN, INC. |
发明人 |
MCNAUGHTON-SMITH GRANT ANDREW;RIGDON GREGORY COOKSEY;STOCKER JONATHAN WALTER |
分类号 |
A61K31/165;C07C233/11;(IPC1-7):A61K31/165;C07C233/65 |
主分类号 |
A61K31/165 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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