| 摘要 |
PROBLEM TO BE SOLVED: To provide a method and a material for the analysis of allele variation in the PDH(human pyruvic acid dehydrogenase) E1βgene and provide the use of PDH E1βpolymorphism for the diagnosis and treatment of diseases to which the control of pyruvic acid dehydrogenase activity is effective for the treatment such as diabetes, asthma, obesity, sepsis and peripheral vessel diseases. SOLUTION: The objective method for the diagnosis of the polymorphism of human PDH E1βgene comprises the determination of human nucleic acid sequences of the PDH E1βgene at 457th, 1191st, 1198th and/or 1342nd positions defined by the positions in the sequence No.1 (refer to the specification) and the determination of the constitution of the person by referring to the polymorphism in the PDH E1βgene. The invention includes the above method wherein the polymorphism is further defined in a manner described in the specification.
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