发明名称 |
Treatment for juvenile diabetes |
摘要 |
A method for treating diabetes mellitus by administering composition providing a gastrin/CCK receptor ligand, e.g. a gastrin, and an EGF receptor ligand, e.g. TGFalpha, in an amount sufficient to effect differentiation of pancreatic islet precursor cells to mature insulin-secreting cells. The composition can be administered systemically or expressed in situ by cells transgenically supplemented with one or both of a gastrin/CCK receptor ligand gene, e.g. a preprogastrin peptide precursor gene and an EGF receptor ligand gene, e.g. a TGFalpha gene.
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申请公布号 |
US6288301(B1) |
申请公布日期 |
2001.09.11 |
申请号 |
US19980127028 |
申请日期 |
1998.07.30 |
申请人 |
WARATAH PHARMACEUTICALS, INC.;THE GENERAL HOSPITAL CORPORATION |
发明人 |
NARDI RONALD V.;BRAND STEPHEN J. |
分类号 |
A61K38/00;A61K38/22;C07K14/495;C07K14/595;(IPC1-7):A01K67/027;C07H21/02;C07H21/04;C12N15/00;C12N15/09 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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