发明名称 |
Substrates and inhibitors for cysteine protease ICH-1 |
摘要 |
Substrates and inhibitors for the cysteine protease Ich-1 are disclosed. These compounds are designed based on an optimal minimal substrate for Ich-1 and include reversible inhibitors, irreversible inhibitors, selectively reversible inhibitors, chromogenic substrates, fluorogenic substrates and radiolabeled substrates/inhibitors. Pharmaceutical compositions comprising the compounds of the invention are also provided. Methods for inhibiting the proteolytic activity of Ich-1, methods for detecting the presence of Ich-1 and methods for isolating Ich-1 using the compounds of the invention are also disclosed.
|
申请公布号 |
US6288037(B1) |
申请公布日期 |
2001.09.11 |
申请号 |
US19960665643 |
申请日期 |
1996.06.18 |
申请人 |
BASF AKTIENGESELLSCHAFT;WARNER-LAMBERT COMPANY |
发明人 |
TALANIAN ROBERT V.;GHAYUR TARIQ;HODGES JOHN C. |
分类号 |
C12N9/99;A61K31/00;A61K38/00;A61K38/55;A61P25/28;A61P43/00;C07K1/22;C07K5/103;C07K7/06;C07K14/81;(IPC1-7):A61K38/07;C07K5/10 |
主分类号 |
C12N9/99 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|