摘要 |
PROBLEM TO BE SOLVED: To provide a compound capable of suppressing the formation of inflammatory cytokine. SOLUTION: The objective compound is expressed by general formula (I) A is pyrrole ring; R1 is a (substituted)aryl or a (substituted)heteroaryl; R2 is a (substituted)heteroaryl; R3 is a group expressed by general formula X-R4 [X is single bond, a (substituted)alkylene, a (substituted)alkenylene or a (substituted)alkynylene; and R4 is a substituted cycloalkyl, a substituted aryl, a (substituted)heterocyclyl, a (substituted)heteroaryl or NRaRb (Ra and Rb are each H, an alkyl, an alkenyl, an alkynyl, an aralkyl or an alkylsulfonyl)]; the atoms on the pyrrole ring bonded with R1 and R3 are each adjacent to the atom on the pyrrole ring bonded with R2} or its pharmacologically permissible salts, esters or other derivatives.
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