METHODS OF USING A FACILITATOR OF RETROVIRAL ENTRY INTO CELLS
摘要
The present invention demonstrates that a receptor, named DC-SIGN, is specifically expressed on dendritic cells, and facilitates infection of T lymphocytes with HIV. Assays for identifying compounds that modulate the interaction of DC-SIGN and HIV and/or T cells and macrophage are provided. Compounds so identified are also part of the present invention.
申请公布号
WO0164752(A2)
申请公布日期
2001.09.07
申请号
WO2001US06322
申请日期
2001.02.28
申请人
NEW YORK UNIVERSITY;KATHOLIEKE UNIVERSITEIT NIJMEGEN;LITTMAN, DAN, R.;KWON, DOUGLAS;VAN KOOYK, YVETTE;GEIJTENBEEK, TEUNIS
发明人
LITTMAN, DAN, R.;KWON, DOUGLAS;VAN KOOYK, YVETTE;GEIJTENBEEK, TEUNIS