摘要 |
PURPOSE: Provided is a manufacture method of 2-oxo-1,3-dibenzyl-cis-4,5-imidazolidine dicarboxylic acid or 2-oxo-1,3-dibenzyl-cis-4,5-imidazolidine dicarboxylic anhydride by using dialkali metal salt type of meso-2,3-bis(benzylamino)succinic acid as a starting material. CONSTITUTION: The manufacture method comprises the steps of: reacting meso-2,3-bis(benzylamino)succinic acid with phenyl chloroformate in a solvent system consisting of water miscible ether and alkali metal hydroxide solution in a ratio of 2:1 to 1:1; converting the produced 2-oxo-1,3-dibenzyl-cis-4,5-imidazolidine dicarboxylic acid dialkali metal salt into 2-oxo-1,3-dibenzyl-cis-4,5-imidazolidine dicarboxylic acid by oxidization; or heating the 2-oxo-1,3-dibenzyl-cis-4,5-imidazolidine dicarboxylic acid with acetic anhydride in aromatic hydrocarbon as an organic solvent, to convert it into 2-oxo-1,3-dibenzyl-cis-4,5-imidazolidine dicarboxylic anhydride.
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