发明名称 |
HUMAN SCHIZOPHRENIA GENE |
摘要 |
Nucleic acids comprising the neuregulin 1 gene (NRG1) and encoding NRG1 polypeptides are disclosed. Also described are related nucleic acids encoding NRG1 polypeptides; NRG1 polypeptides; antibodies that bind to NRG1 polypeptides; methods of diagnosis of susceptibility to schizophrenia; assays for agents that alter the activity of NRG1 polypeptide or which identify NRG1 binding agents, and the agents or binding agents identified by the assays; NRG1 therapeutic agents, including the NRG1 nucleic acids, NRG1 polypeptides, or agents that alter the activity of an NRG1 polypeptides; pharmaceutical compositions comprising the NRG1 therapeutic agents; as well as methods of therapy of schizophrenia.
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申请公布号 |
WO0164877(A2) |
申请公布日期 |
2001.09.07 |
申请号 |
WO2001US06377 |
申请日期 |
2001.02.28 |
申请人 |
DECODE GENETICS EHF;STEFANSSON, HREINN;STEINTHORSDOTTIR, VALGERDUR;GULCHER, JEFFREY, R. |
发明人 |
STEFANSSON, HREINN;STEINTHORSDOTTIR, VALGERDUR;GULCHER, JEFFREY, R. |
分类号 |
G01N33/50;A61K31/7088;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P25/18;C07K14/475;C07K14/485;C07K16/18;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/12;C12P21/02;C12Q1/68;G01N33/15;G01N33/53;G01N33/566;(IPC1-7):C12N15/12;C12N15/10;C12N15/66;C12N15/62;C07K16/22;G01N33/68;G01N33/577;A61K38/18;A61K31/70;A01K67/027 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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