SURGICAL ANESTHESIA DELIVERY SYSTEM

摘要

A system, including composition and delivery device, for the delivery of anesthetics such as lidocaine in the course of soft tissue surgery, e.g., soft tissue ablation, dissection and debulking. The system finds particular use in the delivery of anesthetics such as lidocaine to urothelial surfaces and periurethelial tissues in the course of minimally invasive surgical prostatic procedures such as transurethral needle ablation (TUNA). A composition can be delivered in the form of a low viscosity gel or solution at ambient temperatures, and is adapted to form a highly viscous solution or gel in situ by increasing its viscosity in response to the elevated body temperatures or suitable means. Once gelled in situ, the composition can serve as a drug reservoir sufficient to hold the anesthetic in place, and optionally, can also serve as a conductive medium for iontophoretic delivery.