发明名称 |
INDANE DERIVATIVES AND THEIR USE AS CELL ADHESION INHIBITORS |
摘要 |
The invention is directed to physiologically active compounds of general formula (I) wherein: R1 represents aryl, heteroaryl or a group R3-L2-Ar1-L3- ; R2 represents hydrogen or lower alkyl; R3 represents aryl or heteroaryl; and Ar1 represents an optionally substituted saturated, partially saturated or fully unsaturated 8 to 10 membered bicyclic ring system containing at least one heteroatom selected from O, S or N; Y is carboxy or an acid bioisostere; and their corresponding N-oxides or prodrugs, and pharmaceutically acceptabl e salts and solvates of such compounds and their corresponding N-oxides or prodrugs. Such compounds have valuable pharmaceutical properties, in particular the ability to regulate the interaction of VCAM-1 and fibronectin with the integrin VLA-4(.alpha.4.beta.1).
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申请公布号 |
CA2401441(A1) |
申请公布日期 |
2001.09.07 |
申请号 |
CA20012401441 |
申请日期 |
2001.02.28 |
申请人 |
AVENTIS PHARMA LIMITED |
发明人 |
MCCARTHY, CLIVE;FENTON, GARRY;MORLEY, ANDREW DAVID;MACKENZIE, ROBERT EDWARD |
分类号 |
A61K31/423;A61P11/06;A61P29/00;C07D235/30;C07D263/58;(IPC1-7):C07D263/58;A61K31/418 |
主分类号 |
A61K31/423 |
代理机构 |
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