RECOMBINANT SENDAI VIRUS VECTOR FOR INTRODUCING EXOGENOUS GENES TO AIRWAY EPITHELIA
摘要
Provided are a recombinant Sendai virus vector for introducing exogenous genes to airway epithelia and a method for introducing exogenous genes using the vector. The recombinant Sendai virus vector enables efficient gene transfer to native mucus-layered airway epithelial cells by briefly contacting the vector with the cells. Furthermore, the vector can introduce genes to not only apical surfaces but also submucosal glands where CFTR primarily expresses. The vector can thus be used for gene therapy of CF, a CFTR-deficient disease.
申请公布号
WO0132898(A3)
申请公布日期
2001.09.07
申请号
WO2000JP07737
申请日期
2000.11.02
申请人
DNAVEC RESEARCH INC.;YONEMITSU, YOSHIKAZU;HASEGAWA, MAMORU;ALTON, ERIC, WFW