GENE RECOMBINANT ANTIBODY AND ANTIBODY FRAGMENT THEREOF

摘要

A gene recombinant antibody or its fragment specifically reacting with the extracellular domain of human CCR4; a DNA encoding this gene recombinant antibody or its fragment; a process for producing this gene recombinant antibody or its fragment; a method of immunologically detecting CCR4, a meth od of immunologically detecting cells with the expression of CCR4 on the surfac e thereof, a method of lessening or eliminating cells with the expression of CCR4 on the surface thereof, and a method of inhibiting the production of Th 2 cytokine, each by using the above gene recombinant antibody or its fragment; and drugs, remedies or diagnostics for Th2-mediated immune diseases and remedies or diagnostics for blood cancer each containing the above gene recombinant antibody or its fragment as the active ingredient.