CHROMAN DERIVATIVES AS ESTROGENIC COMPOUNDS

摘要

The invention provides chroman compounds having Formula (1), wherein R<1> is (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl, and independently R<1> has a cis-orientation in relation to the exocyclic phenyl group at the 2-position of the skeleton; R<4> is Hal, CF3, OH or (1C-2C)alkyloxy; R<2>, R<3>, and R<5> are independently H, Hal, CF3, (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl and prodrugs thereof for the manufacture of a medicine for estrogen-receptor related treatments.