EPITHELIALES MEMBRANPROTEIN-1

摘要

Epithelial membrane protein-1 (EMP-1) was identified as having a high degree of homology with peripheral myelin protein 22 (PMP22) and was expressed predominantly in the digestive tract and the nervous system. EMP-1 and PMP22 define a novel family of transmembrane proteins which are involved in the regulation of cell growth and/or differentiation. Included in the invention are EMP-1 nucleic acids, and expression vectors and host cells for the recombinant production of EMP-1. Nucleic acids are used to detect EMP-1 mutation in biological samples and to treat EMP-1 related conditions by anti-sense or gene therapy. Host cells displaying EMP-1 are used to screen for EMP-1 ligands and for receptor agonists and antagonists.