Modulators of regulatory protein RS1, useful for treating diabetes or tumors and for increasing drug transport, control concentration of transport proteins in plasma membranes

摘要

Compound (I) for regulating the concentration of transport proteins (TP) in the plasma membrane of cells that acts by modifying the activity or concentration of the regulatory protein RS1. Independent claims are also included for the following: (1) expression vector containing a nucleic acid (II) that (i) encodes a ribozyme or antisense RNA, directed against mRNA of RS1, or an antibody against RS1, or (ii) encodes RS1 or its fragments; and (2) cells that contain the vector of (1) or in which the RS1-encoding gene has been inactivated or deleted.