| 摘要 |
This invention provides compounds of Formula I having the structure wherein B and D are each, independently, hydrogen, halogen, -CN, alkyl of 1-6 carbon atoms, aryl, or aralkyl of 6-12 carbon atoms; R1 is hydrogen, alkyl of 1-6 carbon atoms, -CH(R2)W, -C(CH3)2CO2R3, 5-thiazolidine-2,4-dione, -CH(R4)CH2CO2R3, -COR3, or -PO3(R3)2; R2 is hydrogen, alkyl of 1-6 carbon atoms, aralkyl of 6-12 carbon atoms, aryl, -CH2(1H-imidazol-4-yl), -CH2(3-1H-indolyl), -CH2CH2(1,3-dioxo-1,3-dihydro-isoindol-2-yl), -CH2CH2(1-oxo-1,3-dihydro-isoindol-2-yl), or -CH2(3-pyridyl); W is -CO2R3, -CONH2, -CONHOH, -CN, CONH(CH2)2CN, 5-tetrazole, or -PO3(R3)2; R3 is hydrogen, alkyl of 1-6 carbon atoms, or, aryl; R4 is hydrogen or alkyl of 1-6 carbon atoms; or a pharmaceutically acceptable salt thereof, which are useful in treating, metabolic disorders related to insulin resistance or hyperglycemia
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