METHOD FOR FORMING INCLUSION COMPLEX OF CONTRAST MEDIA AND CYCLODEXTRIN OR DERIVATIVES THEREOF

摘要

PURPOSE: A method for forming an inclusion complex of contrast media and cyclodextrin or derivatives thereof by reacting contrast media and cyclodextrin or derivatives thereof is provided. Whereby, the complex minimizes adverse effects by shielding an adverse effect-inducing factor not to directly contact with a biomaterial. CONSTITUTION: The inclusion complex of contrast media and cyclodextrin or derivatives thereof is obtained by mixing cyclodextrin or derivatives thereof and contrast media in a mole ratio of 1:1 to 10:1 for 0.1 hr to 7 days and can be used as contrast media in vivo. The contrast media is selected from the group consisting of sodium diatrizoate, ioversol, iohexol, iopromide and mixtures thereof.