| 摘要 |
<p>PCT No. PCT/GB92/02231 Sec. 371 Date Jun. 1, 1994 Sec. 102(e) Date Jun. 1, 1994 PCT Filed Dec. 1, 1992 PCT Pub. No. WO93/11131 PCT Pub. Date Jun. 10, 1993 beta -lactam antibiotics of formula (I) or a salt thereof, wherein R1 is hydrogen, methoxy of formamido; R2 is an acyl group, in particular that of an antibacterially active cephalosporin; CO2R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy protecting group (such as a pharmaceutically acceptable in vivo hydrolysable ester group); R4 represents up to four substituents selected from alkyl, alkenyl, alkynyl, alkoxy, hydroxy, halogen, amino, alkylamino, acylamino, dialkylamino, CO2R, CONR2, SO2NR2 (where R is hydrogen or C1-6 alkyl), aryl and heterocyclyl, which may be the same or different and wherein any R4 alkyl substituent is optionally substituted by any other R4 substituent; X is S, SO, SO2, O or CH2; Y is S, SO or SO2; and m is 1 or 2, useful in the treatment of bacterial infections in humans and animals. <IMAGE> (I)</p> |
