| 发明名称 |
Activated vitronectin as a marker of angiogenesis detected with phage antibodies |
| 摘要 |
<p>The present invention provides a method for producing antibody fragments that discriminate between native and activated vitronectin, which can be used as markers of angiogenesis. Also provided are antibodies and peptides comprising said fragments, and therapeutic methods, particularly related to targeting for antibody-mediated anti-vascular cancer therapy and inhibiting the adhesion and migration of tumor-endothelial cells and platelets.</p> |
| 申请公布号 |
EP1130099(A1) |
申请公布日期 |
2001.09.05 |
| 申请号 |
EP20010200711 |
申请日期 |
2001.02.26 |
| 申请人 |
CRUCELL HOLLAND B.V. |
发明人 |
VOEST, EMILE EUGENE;BLOEMENDAL, HENRI JOHAN;DE BOER, HENRIETTE CHRISTINE;GEBBINK, MARTIJN FRANS BEN GERARD;LOGTENBERG, TON |
| 分类号 |
A61P35/00;C07K14/78;C07K16/18;C12N15/12;C12N15/13;(IPC1-7):C12N15/13;A61K39/395;G01N33/68;G01N33/577;C07K19/00 |
主分类号 |
A61P35/00 |
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