MONOCLONAL ANTIBODIES RECOGNIZING THE EPIDERMAL GROWTH FACTOR-RECEPTOR, CELLS AND METHODS FOR PRODUCING THEM AND COMPOSITIONS CONTAININGTHEM

摘要

The present invention relates to a monoclonal antibodies capable of recognizing the EGF receptor in human placenta or A-431 cells with high affinity and capable of inhibiting EGF binding to the receptor. The monoclonal antibodies also has the ability to produce antibody dependent cellular cytotoxicity; to develop complement-mediated cytotoxic activity; to inhibit tumoral growth in certain cell lines and to show a synergetic effect to inhibit these cell lines proliferation when they are in combination with gangliosides or monoclonal antibodies against EGF.