| 摘要 |
This invention relates to therapeutic reagents and peptides, including radio therapeutic reagents and peptides, radiodiagnostic reage nts and peptides, and methods for producing labeled radiodiagnostic agents. Spe cifically, the invention relates to cyclic peptide deriv atives and analogs of somatostatin, and embodiments of such peptides radiolabeled w ith a radioisotope, as well as methods and kits for maki ng, radiolabeling and using such peptides for radiodiagnostic and radiotherapeut ic purposes. The invention specifically relates to cycl ic peptide derivatives and analogues of somatostatin radiolabeled with technetium-99m a nd uses thereof as scintigraphic imaging agents. The in vention also specifically relates to cyclic peptide derivatives and analogues of som atostatin radiolabeled with cytotoxic radioisotopes such as rhenium- 186 (186Re) and rhenium-188 (188Re) for use as radiotherapeutic agents. Met hods and kits for making, radiolabeling and using such p eptides diagnostically and therapeutically in a mammalian body are also provided.</S DOAB>
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