发明名称 |
Carbohydrazide protease inhibitors |
摘要 |
The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, inducing osteoporosis; gingival disease including gingivitis and periodontists; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.
|
申请公布号 |
US6284777(B1) |
申请公布日期 |
2001.09.04 |
申请号 |
US20000552616 |
申请日期 |
2000.04.19 |
申请人 |
SMITHKLINE BEECHAM CORPORATION |
发明人 |
HALBERT STACIE MARIE;THOMPSON SCOTT KEVIN |
分类号 |
A61K31/00;A61K31/16;A61K31/18;A61K31/34;A61K31/343;A61K31/38;A61K31/381;A61K31/41;A61K31/415;A61K31/4155;A61K31/4164;A61K31/4245;A61K31/425;A61K31/426;A61K31/427;A61K31/433;A61K31/44;A61K31/4427;A61K31/443;A61K31/4439;A61K31/445;A61K31/4465;A61K31/4523;A61K31/4525;A61K31/47;A61K31/4709;A61K31/495;A61K31/496;A61K31/4965;A61K31/497;A61K31/535;A61K31/5375;A61K31/5377;A61K31/54;A61K38/00;A61P1/00;A61P1/02;A61P19/00;A61P19/10;A61P29/00;A61P43/00;C07C235/50;C07C243/34;C07C271/22;C07C281/06;C07C311/16;C07C311/29;C07D211/62;C07D213/30;C07D213/71;C07D213/81;C07D215/36;C07D231/18;C07D233/56;C07D241/24;C07D249/10;C07D271/06;C07D271/10;C07D277/20;C07D277/36;C07D277/40;C07D277/56;C07D285/06;C07D285/12;C07D285/125;C07D285/135;C07D295/155;C07D295/20;C07D295/215;C07D307/91;C07D333/34;C07D333/76;C07D401/12;C07D405/12;C07D417/12;C07D417/14;C07K5/062;C07K5/083;C12N9/64;C12Q1/37;G01N33/573;(IPC1-7):A61K31/440;A61K31/440;A61K31/444 |
主分类号 |
A61K31/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|