| 摘要 |
A compound represented by the formulae (A) or (B) wherein R1 is H, R5, (a), (b), (c), (d), (e), (f), (g), — (CH2)nOC(O)R5, —(CH2)nOR5, or —(CH2)n-N-R6; each R2 and R3 individually is H, (CH2)mOH, -C(O)OR, -C(O)R5, -C(O)SR, (CH2)m-C(O)-NR5R'5, -O-C(O)-O-R5, an amino acid and/or a dipeptide; R is R5, H, (h), (i), (j), (k), (l), (m) or (n); R4 is H, OH, -OC(O)-R5, -OC(O)-N-R5(R'5), -O-C(O)-O-R5; each R5, R'5, and R5'' is independently H, alkyl, substituted alkyl, aryl, substituted aryl, alkenyl, alkynyl, substituted alkenyl, substituted alkynyl, heterocycle, substituted heterocycle, alkylaryl, substituted alkylaryl, cycloalkyl, substituted cycloalkyl, or -CH2CO2 alkyl; and wherein R5 can also be (dialkyl)CO alkyl; -NR6 is (o), (p), (q), (r) or (s) each R7 and R'7 individually is alkyl, alkylaryl, substituted alkylaryl, cycloalkyl, substituted cycloalkyl; R8 is alkyl, or halo substituted alkyl; n=1-5 and m=0-4; and pharmaceutically acceptable salts thereof; and method of preparation are provided. Compounds of the above formulae are useful as prodrugs for compounds that are useful as neuraminidase inhibitors. Accordingly, they may be used for preventing, treating or ameliorating infections including viral and bacterial. |
