Degradation fragments

摘要

A pharmaceutical composition comprising a compound of formula (I) wherein X is an electron withdrawing group, Y¹ is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, -SO₂R⁴, -CO₂R⁴, -CONHR⁴ or -COR⁴, and each of R¹, R² and R⁴, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, or a compound of formula (II) wherein each of Y² and Y³, which may be the same or different, is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, -SO₂R⁹, -CO₂R⁹, -CONHR⁹ or -COR⁹, Z is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclyl, -CH-C(NHR¹⁰)CH((CH₂)_mCO₂R¹¹)(C-O)CH₃ or -CH₂(C-O)CH((CH₂)_mCO₂R¹¹)(C-O)CH₃, R⁸ is -(CH₂)_nCO₂R¹², each of R⁵ to R⁷ and R⁹ to R¹², which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, and each of m and n, which may be the same or different, is 1 to 6 or a compound of formula (III) wherein each of Y⁴ to Y⁶, which may be the same or different, is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, -SO₂R¹⁹, -CO₂R¹⁹, -CONHR¹⁹ or -COR¹⁹, each of R¹⁶ and R¹⁷, which may be the same or different, is -(CH₂)_pCO₂R²⁰, each of R¹³ TO R¹⁵ and R¹⁸ to R²⁰, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, and p is 1 to 6, or other photolabile degradation product of bilirubin or biliverdin or derivative of a photolabile degradation fragment of bilirubin or biliverdin, or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier or diluent