Process for the preparation of 11-amino-3-chloro-6,11-dihydro-5,5-dioxo-6-methyl-dibenzo[c,f][1,2]thiazepine and application to the synthesis of tianeptine

摘要

A process for the industrial synthesis of 11-amino-3-chloro-6,11-dihydro-5,5-dioxo-6-methyl-dibenzo[c,f][1,2]thiazepine tianeptine of formula (I) is described. The compound of formula (I) is an intermediate in the synthesis of the tianeptine of formula (II) which stimulates serotonin uptake as outlined in Patent Specification FR 2 104 728.