发明名称 |
METHOD FOR PRODUCING COX-2 INHIBITORS |
摘要 |
The invention relates to a method for producing compounds of general formula (I) wherein R1 is selected from the following groups: (a) OR5 and (b) mono-, di-, or tri-substituted phenyl; and R2 represents a group (C1-C6)alkyl. The method is characterised in that it comprises the following steps: a) reacting a compound of general formula (II) with an acid of general formula R1CH2 COOH (III) in a water-free medium; b) reacting the resulting compound with a strong base in an aprotic solvent in order to obtain an intermediate cyclic compound which forms a compound of general formula (I) after dehydration; and c) isolating said resulting compound of general formula (I).
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申请公布号 |
WO0127098(A3) |
申请公布日期 |
2001.08.30 |
申请号 |
WO2000FR02770 |
申请日期 |
2000.10.05 |
申请人 |
MERIAL;CANALI, LAETITIA;CRUCIANI, PAUL;ODDON, GILLES |
发明人 |
CANALI, LAETITIA;CRUCIANI, PAUL;ODDON, GILLES |
分类号 |
A61K31/341;A61P29/00;C07C323/19;C07D307/60;(IPC1-7):C07D307/60 |
主分类号 |
A61K31/341 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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