18607, A NOVEL HUMAN CALCIUM CHANNEL

摘要

The invention provides isolated nucleic acids molecules, designated TLCC nucleic acid molecules, which encode novel TRP-like calcium channel molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TLCC nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a TLCC gene has been introduced or disrupted. The invention still further provides isolated TLCC proteins, fusion proteins, antigenic peptides and anti-TLCC antibodies. Diagnostic methods utilizing compositions of the invention are also provided.