摘要 |
The present invention provides methods and compositions for screening, diagnosis and prognosis of Schizophrenia, for monitoring the effectiveness of Schizophrenia treatment, identifying patients most likely to respond to a particular therapeutic treatment and for drug development. Schizophrenia-Associated Features (SFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Schizophrenia-Associated Protein Isoforms (SPIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated SPIs, antibodies immunospecific for SPIs, and kits comprising the aforesaid.
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申请人 |
OXFORD GLYCOSCIENCES (UK) LTD.;HERATH, HERATH, MUDIYANSELAGE, ATHULA, CHANDRASIRI;PAREKH, RAJESH, BHIKHU;ROHLFF, CHRISTIAN;TERRETT, JONATHAN, ALEXANDER;TYSON, KERRY, LOUISE |
发明人 |
HERATH, HERATH, MUDIYANSELAGE, ATHULA, CHANDRASIRI;PAREKH, RAJESH, BHIKHU;ROHLFF, CHRISTIAN;TERRETT, JONATHAN, ALEXANDER;TYSON, KERRY, LOUISE |