METHOD OF SCREENING COMPOUNDS FOR BIOLOGICAL ACTIVITY

摘要

The present invention provides a method of screening compounds to identify ligands that bind to specific target molecules using nuclear magnetic resonance (NMR) and the measurement of residual dipolar couplings. The metho d is particularly useful in screening and/or identifying compounds which bind to specific target molecules, for example proteins, polypeptides and macromolecules so as to assist in rational drug design.