A process for purifying statin compounds from a fermentation broth by extraction and crystallization is disclosed. A fermentation broth is subjected to a pretreatment procedure which involves an alkaline pretreatment and an alkaline purification. Following the pretreatment procedure, the statin compound is extracted under acidic conditions into a hydrophobic solvent and purified by crystallization. The organic extraction solvent is concentrated and then extracted with a mild base. The statin compound is then purified by crystallization.
申请公布号
WO0162949(A1)
申请公布日期
2001.08.30
申请号
WO2001US02505
申请日期
2001.01.25
申请人
BIOGAL GYOGYSZERGYAR RT;TEVA PHARMACEUTICALS USA, INC.;KERI, VILMOS;DEAK, LAJOS;FORGACS, ILONA