CATIONIC AMPHIPHILIC 1,4-DIHYDROPYRIDINE DERIVATIVES USEFUL FOR DELIVERY OF NUCLEOTIDE CONTAINING COMPOUNDS

摘要

The present invention discloses amphiphilic 1,4-dihydropyridine derivatives useful for the preparation of a composition for delivering nucleotide containing compounds into a target cell and/or its nucleus. Said composition comprises 1,4-dihydropyridine derivatives having a good DNA condensing capacity and capability of self-association. Also disclosed are composition comprising said derivatives complexed with nucleotide containing compounds a s well methods for the producing of said complexes. The invention is also related to the use of said 1,4-dihydropyridine derivatives for manufacturing systems for delivering nucleotide containing compounds useful in gene therap y and DNA vaccination.