发明名称 |
METHOD OF PURIFYING A FERMENTATION BROTH |
摘要 |
A process for purifying statin compounds from a fermentation broth by extraction and crystallization is disclosed. A fermentation broth is subject ed to a pretreatment procedure which involves an alkaline pretreatment and an alkaline purification. Following the pretreatment procedure, the statin compound is extracted under acidic conditions into a hydrophobic solvent and purified by crystallization. The organic extraction solvent is concentrated and then extracted with a mild base. The statin compound is then purified by crystallization.
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申请公布号 |
CA2400952(A1) |
申请公布日期 |
2001.08.30 |
申请号 |
CA20012400952 |
申请日期 |
2001.01.25 |
申请人 |
BIOGAL GYOGYSZERGYAR RT. |
发明人 |
KERI, VILMOS;DEAK, LAJOS;FORGACS, ILONA |
分类号 |
C12P17/06;A61K31/351;A61P9/00;A61P9/10;C07D;C07D309/30;C12N;C12N9/99;C12P;C12P7/62;C12P17/02;(IPC1-7):C12P17/06 |
主分类号 |
C12P17/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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