摘要 |
<p>Disclosed is a microarray printing system (100) and methods of printing probe microarrays (1101). The system has a print head (101, 200, 805, 1003, 1700, 1800, 1900) formed of one or more bundles (201-221, 604) of individual capillaries, (102, 301, 402a, 402b, 502a, 502b, 603a, 603b, 802) such as light-guiding capillaries. The bundles may especially be random bundles of capillaries that provide a large number of probes (807, 1006a, 1006b, 1206) on the surface of a substrate. Methods of registering or correlating the distal and proximal ends of the capillaries are also provided. Further, the invention provides methods and equipment for identifying defective microarrays that are missing one or more probes from the surface of the microarray.</p> |