| 摘要 |
<p>Concurrent administration of antigen-pulsed dendritic cells and activated T cells to a patient is disclosed. Such administration results in maturation of dendritic cells, which allows dendritic cells to enter the lymph system. Co-administration of antigen-pulsed dendritic cells and activated T cells induce bidirectional stimulation in each cell population. As a result, cytokine productions such as IFN-η and IL-12 are greatly enhanced, and a Th1 type of immunologic response specific against the antigens is induced. The methods therefore elicit an immune response in a patient, and find application in the treatment of cancer, immune diseases, and viral infections. Formulations comprising the dendritic cells and activated T cells of the present invention are also disclosed.</p> |
