发明名称 |
CASPASE ACTIVATED PRODRUGS THERAPY |
摘要 |
The invention provides novel methods for the localized delivery of pharmaceutical agents by the administration of a caspase conjugate that targets a cell type of interest and the additional administration of a pro-agent that is locally converted, in the presence of the caspase, to an active agent. The invention further provides novel tageting agents comprising a caspase as well as novel prodrugs comprising a caspase cleavable prodrug moiety. The invention also provides pharmaceutical compositions as well as methods of treatment comprising the caspase conjugates and prodrugs of the invention
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申请公布号 |
WO0162300(A2) |
申请公布日期 |
2001.08.30 |
申请号 |
WO2001US05709 |
申请日期 |
2001.02.22 |
申请人 |
GENENTECH, INC.;CARTER, PAUL, J.;GAZZARD, LEWIS |
发明人 |
CARTER, PAUL, J.;GAZZARD, LEWIS |
分类号 |
A61K31/337;A61K31/475;A61K31/704;A61K38/46;A61K39/395;A61K45/08;A61K47/48;A61P35/00;A61P43/00;C07K16/32;(IPC1-7):A61K47/48 |
主分类号 |
A61K31/337 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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