摘要 |
PURPOSE: A method for producing 2-chloropyridine is provided, thereby the title compound having the improved stereo-selectivity can be cheaply produced in higher yield. CONSTITUTION: 2-chloropyridine of the formula is produced by solubilizing pyridine-1-oxide in organic solvent and reacting the mixture at from 0 deg. C to below boiling temperature of solvent in the presence of chlorinating agents and base, in which the chlorinating agents are phosphoryl chloride, thionyl chloride, sulfunyl chloride, p-toluenesufonyl chloride, benzensulfonyl chloride, and methanesulfonyl chloride, and base is selected from inorganic base such as potassium carbonate, sodium carbonate, ammonium carbonate, lower alkyl amine, lower dialkyl amines, lower trialkyl amines, aniline, N-methylaniline, N,N-dimethylaniline, and lower alkoxides.
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