发明名称 |
Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor |
摘要 |
In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species. Accordingly, the interaction of at least one member of the steroid/thyroid superfamily of receptors with at least the dimerization domain of the ultraspiracle receptor modulates the ability of said member of the steroid/thyroid superfamily of receptors to transactivate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said member of the superfamily.
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申请公布号 |
US6281330(B1) |
申请公布日期 |
2001.08.28 |
申请号 |
US19950486403 |
申请日期 |
1995.06.05 |
申请人 |
THE SALK INSTITUTE BIOLOGICAL STUDIES |
发明人 |
EVANS RONALD M.;MC KEOWN MICHAEL B.;ORO ANTHONY E.;SEGRAVES WILLIAM A.;YAO TSO-PANG |
分类号 |
G01N33/53;A61K38/00;A61K48/00;C07K14/44;C07K14/705;C07K14/72;C12N1/21;C12N5/10;C12N15/09;C12N15/85;C12P21/02;C12Q1/68;C12R1/91;G01N33/15;(IPC1-7):C07K5/00 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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