摘要 |
<p>PROBLEM TO BE SOLVED: To provide a method for simply producing a coupler for photography in a high yield, and to provide a method for simply producing an agent such as a medicine or an agrochemical or its organic synthetic intermediate in a high yield. SOLUTION: This method for producing a coupler and an organic synthetic intermediate, comprising the nucleophilic substitution reaction of an active methylene compound of the general formula (1): X-CH2-EWG (X is an alkylthio, an arythio, or a heteroarylthio; EWG is nitrile, carbamoyl, an aryloxycarbonyl, or an alkoxycarbonyl) with an aromatic heterocyclic compound of the general formula (2) [Y is a halogen atom, an alkylsulfonyl, or an arylsulfonyl.</p> |