| 发明名称 |
Amine derivatives for the treatment of apoptosis |
| 摘要 |
The present invention is related to substituted amine derivatives I notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such piperazine derivatives of carbazole. Said substituted amine derivatives are efficient modulators, in particular inhibitors, of the Bax function and/or activation. The present invention is furthermore related to novel substituted amine derivatives as well as methods of their preparation. <CHEM> A<1> and A<2> are selected independently from each other from the group consisting of -C(O)- and -SO2-. R<a>, R<b>, R<0>, R<1> and R<2> are as the application. |
| 申请公布号 |
AU5464001(A) |
申请公布日期 |
2001.08.27 |
| 申请号 |
AU20010054640 |
申请日期 |
2001.02.13 |
| 申请人 |
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. |
发明人 |
SERGE HALAZY;MATTHIAS SCHWARZ;BRUNO ANTONSSON;AGNES BOMBRUN;JEAN-CLAUDE MARTINOU;DENNIS CHURCH |
| 分类号 |
A61K31/164;A61K31/165;A61K31/40;A61K31/401;A61K31/425;A61K31/426;A61K31/445;A61K31/47;A61K31/472;A61P1/00;A61P1/16;A61P7/00;A61P9/04;A61P9/08;A61P9/10;A61P11/06;A61P13/12;A61P15/00;A61P15/12;A61P19/02;A61P21/00;A61P25/00;A61P25/08;A61P25/14;A61P25/16;A61P25/28;A61P27/02;A61P29/00;A61P31/18;A61P37/02;A61P43/00;C07C231/02;C07C231/04;C07C233/00;C07C235/00;C07C237/22;C07D207/16;C07D211/60;C07D217/26;C07D277/06;C07D277/44 |
主分类号 |
A61K31/164 |
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