PROCEDIMENTO PER OTTENERE DA COLTURE PRIMARIE DI CHERATONOCITI UMANI LINEE CELLULARI IMMORTALIZZATE.

摘要

Immortalised cell lines from primary human keratinocytes cell lines obtained thanks to down regulation of 14-3-3-sigma coding gene. Said immortalised cell lines are extremely useful in in vivo and in vitro studies on cancer development. Infact, immortalization is absolutely required for somatic cells transformation. It is also an object of the present invention the immortalised cell lines obtained thereof.