POLYPEPTOID PULMONARY SURFACTANTS

摘要

The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including fo r the treatment of respiratory distress of the lungs. The spreading agents are sequence-specific oligomers, including retrosequence-specific oligomers, bas ed on a peptide backbone, that are designed as analogs of surfactant protein-B or surfactant protein-C.