发明名称 Pyrimidin-aminomethyl-pyridine derivatives, their preparation and their use in the control of helicobacter bacteria.
摘要 The present invention relates to compounds of formula (I) wherein R1, R2, and R3 are hydrogen, 1-4C-alkyl, or halogen; R4, R5, R6, and R9 are hydrogen or 1-4C-alkyl; R7 and R8 are hydrogen, 1-4C-alkyl, 1-4C-alkoxy, or halogen; A is 1-7C-alkylene, 2-7C-alkenylene, 3-7C-cycloalkylene, or phenylene; G is hydrogen, hydroxyl, 1-7C-alkyl, 1-4C-alkyl substituted by fluorine, 2-7C-alkenyl, 3-7C-cycloalkyl, a mono- or di-1-4C-alkylcarbamoyl or -thiocarbamoyl, N-1-4C-alkyl-N'-cyanoamidino, 1-N-1-4C-alkylamino-2-nitroethylene, N-2-propynyl-N'-cyanoamidino, aminosulfonylamidino, -N(R10)R11, the part of the compound of formula (I) bonded to A, glucopyranoside, or a cyclic system or bicyclic system which is optionally substituted by R12 and R13; X is oxygen, N-1-4C-alkyl, NH, or S; Y is oxygen, N-1-4C-alkyl, NH, S, 1,4-piperazinylene, or 1,4-piperidinylene; Z is oxygen, N-1-4C-alkyl, NH, S, or CO; m is from 1 to 7; n is from 0 to 4; t is 0, 1, or 2; and u is 0 or 1, and their salts suitable for controlling Helicobacter bacteria.
申请公布号 ZA200006633(B) 申请公布日期 2001.08.23
申请号 ZA20000006633 申请日期 2000.11.15
申请人 BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH. 发明人 GUIDO HANAUER;BERNHARD KOHL;STEFAN POSTIUS;SENN, BILFINGER, JOERG;WOLFGANG-ALEXANDER SIMON;WOLFGANG OPFERKUCH;PETER ZIMMERMANN;GERHARD GRUNDLER
分类号 A61K31/505;A61K31/506;A61P1/04;A61P31/04;C07D401/12;C07D401/14;C07D405/14;C07D409/14;C07D413/14;C07D487/04 主分类号 A61K31/505
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