发明名称 |
MATRIX METALLOPROTEINASE INHIBITORS AND USES THEREOF |
摘要 |
Thus the present invention describes novel compounds comprising: 1-10 targeting moieties; a chelator (Ch); and 0-1 linking groups (Ln) between the targeting moiety and chelator; wherein the targeting moiety is a matrix metalloproteinase inhibitor; and wherein the chelator is capable of conjugating to a cytotoxic radioisotope. The present invention also provides novel compositions of the compounds of the invention, kits, and their uses i n treatment of diseases associated with MMPs.
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申请公布号 |
CA2395841(A1) |
申请公布日期 |
2001.08.23 |
申请号 |
CA20012395841 |
申请日期 |
2001.02.15 |
申请人 |
BRISTOL-MYERS SQUIBB PHARMA COMPANY |
发明人 |
NELSON, DAVID J.;DECICCO, CARL P.;CARPENTER, ALAN P., JR.;DURAN, JAMES J.;BARRETT, JOHN A.;RAJOPADHYE, MILIND |
分类号 |
A61K49/00;A61K49/14;A61K51/08;C07D207/26;C07D213/82;C07D267/00;C07D401/12;C07D401/14;C07D413/12;C07F9/6527;(IPC1-7):C07D413/12;A61K51/04;A61K31/395;C07F9/652 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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