发明名称 |
TRANSGENIC ANIMAL MODEL FOR OBESITY EXPRESSING FOXC2 |
摘要 |
According to the invention, a major role for the winged helix protein FOXC2 in regulating energy balance and adiposity is demonstrated. The invention relates to transgenic non-human mammalian animals being capable of expressing the human <i>FOXC2</i> gene in its adipose tissue. The invention also relates to methods for identifying compounds useful for the treatment of medical conditions related to obesity or diabetes, said compounds being capable of stimulating expression of the human <i>FOXC2</i> gene, or being capable of stimulating the biological activity of a polypeptide encoded by the human <i>FOXC2</i> gene. The invention further relates to methods for identifying compounds useful for the treatment of medical conditions related to malnutrition, said compounds being capable of decreasing expression of the human <i>FOXC2</i> gene, or being capable of decreasing the biological activity of a polypeptide encoded by the human <i>FOXC2</i> gene.
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申请公布号 |
WO0160853(A1) |
申请公布日期 |
2001.08.23 |
申请号 |
WO2001SE00339 |
申请日期 |
2001.02.16 |
申请人 |
PHARMACIA AB;ENERBAECK, SVEN;CARLSSON, PETER |
发明人 |
ENERBAECK, SVEN;CARLSSON, PETER |
分类号 |
A01K;A01K67/027;A61K38/00;A61K38/17;C07K14/435;C07K14/575;C12N5/10;C12N15/09;C12N15/85;C12Q1/02;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/566;(IPC1-7):C07K14/435 |
主分类号 |
A01K |
代理机构 |
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代理人 |
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地址 |
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