发明名称 |
HER-2 BINDING ANTAGONISTS |
摘要 |
There is disclosed a pharmaceutical composition for treating solid tumors th at overexpress HER-2, comprising an agent selected from the group consisting of (a) an isolated polypeptide having from about 50 to 79 amino acids taken fro m the sequence of SEQ ID NO. 1 or SEQ ID NO:12, wherein the polypeptide binds to the extracellular domain ECD of HER-2 at an affinity of at least 108, (b) an isolated and glycosylated polypeptide having from about 300 to 419 amino aci ds taken from the sequence of SEQ ID NO:2 or SEQ ID NO:13, wherein the C termin al 79 amino acids are present, and wherein at least three N-linked glycosylatio n sites are present, (c) a monoclonal antibody that binds to the ECD of HER-2, and (d) combinations thereof, with the proviso that the agent cannot be the monoclonal antibody alone, and pharmaceutically acceptable carrier. Also disclosed are prognostic and diagnostic assays. |
申请公布号 |
CA2400473(A1) |
申请公布日期 |
2001.08.23 |
申请号 |
CA20012400473 |
申请日期 |
2001.02.16 |
申请人 |
OREGON HEALTH SCIENCES UNIVERSITY |
发明人 |
EVANS, ADAM;CLINTON, GAIL;HENNER, WILLIAM D. |
分类号 |
G01N33/53;A61K38/00;A61K39/395;A61P1/00;A61P11/00;A61P15/00;A61P35/00;C07K14/47;C07K16/18;C07K16/32;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12Q1/68;G01N33/566;(IPC1-7):C12N15/12;C07K16/00;A61K38/17;G01N33/567;G01N33/574 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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