发明名称 |
CONFORMATION-SPECIFIC ANTI-VON WILLEBRAND FACTOR ANTIBODIES |
摘要 |
The present invention is directed to antibodies and antibody fragments that bind specifically to the active conformation of human von Willebrand factor. Most preferred are recombinantly produced single chain variable immunoglobulin fragments. Because the antibodies or antibody fragments act only at the sites of thrombus formation and do not interfere with the normal activity of circulating platelets, they are particularly well suited for use as antithrombotic agents in a wide variety of applications. |
申请公布号 |
EP1124856(A1) |
申请公布日期 |
2001.08.22 |
申请号 |
EP19990971002 |
申请日期 |
1999.10.20 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. |
发明人 |
HANDIN, ROBERT, I.;YUAN, HUABING;MCLEOD, ANNE |
分类号 |
G01N33/563;A61K38/00;A61K38/36;A61K39/395;A61P7/02;A61P9/10;C07K16/36;C12N15/02;C12P21/08;C12Q1/68;C12R1/92;(IPC1-7):C07K16/36 |
主分类号 |
G01N33/563 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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