发明名称 |
Coding sequences of the human BRCA1 gene |
摘要 |
<p>isolated coding sequences and to the protein sequences they code for. This invention is directed to three coding sequence of the BRCA1 gene. The three coding sequences, BRCA1<(omi1)>, BRCA1<(omi2)>, and BRCA1<(omi3)> and their frequencies of occurrence are provided together with the protein sequences they code for. Another aspect of this invention is a method of determining the consensus sequence for any gene. Another aspect of the invention is a method of identifying an individual having an increased genetic susceptibility to breast or ovarian cancer because they have inherited a causative mutation in their BRCA1 gene. This invention is also related to a method of performing gene therapy with any of the isolated BRCA1 coding sequences.</p> |
申请公布号 |
EP1126034(A2) |
申请公布日期 |
2001.08.22 |
申请号 |
EP20010107300 |
申请日期 |
1997.02.12 |
申请人 |
GENE LOGIC ACQUISITION CORP. |
发明人 |
MURPHY, PATRICIA D.;ALLEN, ANTONETTE C.;ALVARES, CHRISTOPHER P.;CRITZ, BRENDA S.;OLSON, SHERI J.;SCHELTER, DENISE B.;ZENG, BIN |
分类号 |
C12N15/09;A61K48/00;C07K14/47;C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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