发明名称 |
CASPASE-14, AN APOPTOTIC PROTEASE, NUCLEIC ACIDS ENCODING AND METHODS OF USE |
摘要 |
<p>The invention relates to an isolated nucleic acid molecule encoding a caspase-14 polypeptide or functional fragment thereof, a vector that contains the nucleic acid molecule and a host cell that contains the vector. The invention also relates to an isolated gene encoding caspase-14, as well as functional fragments thereof. The gene or nucleic acid molecule can include single or double stranded nucleic acids corresponding to coding or non-coding strands of the caspase-14 nucleotide sequence. Isolated caspase-14 polypeptides or functional fragments thereof are also provided, as are antibodies that specifically bind thereto. In addition, the invention relates to methods of identifying compounds that modulate caspase-14 activity.</p> |
申请公布号 |
EP1124971(A1) |
申请公布日期 |
2001.08.22 |
申请号 |
EP19990971856 |
申请日期 |
1999.10.29 |
申请人 |
THOMAS JEFFERSON UNIVERSITY |
发明人 |
ALNEMRI, EMAD, S.;FERNANDEZ-ALNEMRI, TERESA |
分类号 |
G01N33/50;A61K38/00;C07K16/40;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/50;C12N9/64;C12N15/09;C12N15/57;C12P21/08;C12Q1/37;G01N33/53;(IPC1-7):C12N15/57 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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